Refine your search
Collections
Co-Authors
Journals
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z All
Dhiman, Anju
- GC-MS Analysis of Bioactives of Jatropha gossypifolia Linn. Leaves
Abstract Views :274 |
PDF Views:81
Authors
Affiliations
1 Department of Pharmaceutical Sciences, Maharshi Dayanand University, Rohtak -124001, Haryana, IN
1 Department of Pharmaceutical Sciences, Maharshi Dayanand University, Rohtak -124001, Haryana, IN
Source
Journal of Pharmaceutical Research, Vol 17, No 1 (2018), Pagination: 13-22Abstract
Purpose: Jatropha gossypifolia Linn. (Family: Euphorbiaceae), is an ornamental ethnomedicinal plant. The leaves of J. gossypifolia L. has been used in treatment of wounds, sores, sprains, rashes, stomach ache, venereal diseases, hemorrhage and tooth infections. The main objective of present research was to carry out the phytochemical screening and Gas Chromatography-Mass Spectrometry (GC-MS) analysis of the leaves of J. gossypifolia L. to evaluate its various bioactive components. Methodology: The bioactive components of the petroleum ether (40-60˚C), chloroform, methanol and aqueous extracts of the leaves were qualitatively analyzed as per the standard methods. The bioactives of leaves of J. gossypifolia were extracted by ultrasonic assisted extraction (UAE) method using methanol as solvent and analyzed by GSMS method using Thermo scientific TSQ 8000 high resolution Gas Chromatograph-Mass Spectrometer. Findings: Maximum bioactive phytocomponents have been reported in methanol leaf extract of J. gossypifolia L. v.i.z. glycosides, phytosterols, saponins, flavonoids, alkaloids, fatty acids, tannins and phenolic compounds. GC-MS analysis separated and identified the presence of 34 phytocomponents in methanolic leaf extract of J. gossypifolia L. The major phytoconstituents identified were 1-Monolinoleoylglycerol trimethylsilyl ether (9.58%); 2, 4-heptadienal (E,E) (6.77%); carotene, 1,1’,2,2’-tetrahydro- 1,1’-dimethoxy (4.92%); ergosta-5,22-dien-3-ol, acetate (4.59%); lanosterol (31.8%) and stigmasterol (2.07%). Cardenolide and bufadienolide derivatives and various fatty acid derivatives like docosanoic acid, 1,2,3-propanetriyl ester; 9,12,15-octadecatrienoic acid, triolein etc. have been also reported in GC-MS analysis. Conclusion: Results of GCMS analysis justified the ethnomedicinal importance of the leaves of J. gossypifolia L. due to presence of various bioactive components belonging to different classes.Keywords
Euphorbiaceae, GCMS, Jatropha gossypifolia L., Lanosterol, Phytochemicals, Stigmasterol.Full Text
References
- Bargah RK. Preliminary test of phytochemical screening of crude ethanolic and aqueous extract of Moringa pterygosperma Gaertn. Journal of Pharmacognosy and Phytochemistry. 2015; 4(1): 7-9.
- Sultana J, Shakil-Ahmed FR. Phytochemical investigations of the medicinal plant Swertia Chirata Ham. Biochemistry and Analytical Biochemistry. 2013; 2(4): 1-7.
- Misra M, Misra AN. Jatropha: the biodiesel plant biology, tissue culture and genetic transformation-a review. International Journal of Pure and Applied Science and Technology. 2010; 1(1): 11-24.
- Felix-Silva J, Giordani RB, Silva-Junior AA, Zucolotto SM, Fernandes-Pedrosa MDF. Jatropha gossypiifolia L. (Euphorbiaceae): a review of traditional uses, phytochemistry, pharmacology, and toxicology of this medicinal plant. Evidence Based Complementary and Alternative Medicine. 2014; 1-32.
- Felix-Silva J, Souza T, Menezes YAS, Cabral B, Camara RBG, Silva-Junior AA et al. Aqueous leaf extract of Jatropha gossypiifolia L. (Euphorbiaceae) inhibits enzymatic and biological actions of Bothrops jararaca snake venom. Plos One. 2014; 9(8): 1-14.
- The Ayurvedic Pharmacopoeia of India, Governement of India, Ministry of Health and Family Welfare. Part I, Volume-V, 2011; 33-35.
- Oduola T, Adeosun GO, Oduola TA, Avwioro GO, Oyeniyi MA. Mechanism of action of Jatropha gossypifolia stem latex as a haemostatic agent. European Journal of General Medicine. 2005; 2(4): 140-43.
- Panda BB, Gaur K, Kori ML, Tyagi LK, Nema RK. Sharma CS et al. Anti-inflammatory and analgesic activity of Jatropha gossypifolia in experimental animal model. Global Journal of Pharmacology. 2009; 3(1): 01-05.
- Jain S, Choudhary GP, Jain DK, Antioxidant and hepatoprotective potential of ethanolic leaves extract of Jatropha gossypifolia. International Journal of Plant Science Ecology. 2015; 1(1): 190-95.
- Ogundare AO. Antimicrobial effect of Tithonia diversifolia and Jatropha gossypifolia leaf extracts. Trends in Applied Science Research. 2007; 2(2): 145-50.
- Kokate CK. Plant constituents. In: Practical Pharmacognosy. 4th ed. Delhi: Vallabh Prakashan; 2007; 107-11.
- Tiwari P, Kumar B, Kaur M, Kaur G, Kaur H. Phytochemical screening and extraction: a review. Internationale Pharmaceutica Sciencia. 2011; 1(1): 98-06.
- Janarthanan S, Vardharajulu RM, Panagal M. Molecular docking identification of best drug molecule from Ipomoea sepiaria (Koenig Ex. Roxb) leaves against type 2 diabetes mellitus. International Journal of Current Biotechnology. 2016; 4(4): 7-12.
- Dr. Duke’s phytochemical and ethnobotanical databases. (Cited 2017 September 15). Available from URL:https:// phytochem.nal.usda.gov/phytochem/chemicals/show/16611?et
- Kumar RP, Sujatha D, Mohamed Saleem TS, Chetty CM, Ranganayakulu D. Potential antidiabetic and antioxidant activities of Morus indicaand Asystasia gangetica in alloxan-induced diabetes mellitus. Journal of Experimental Pharmacology. 2010; 2: 29-36.
- Sheela D, Uthayakumar F. GC-MS analysis of bioactive constituents from coastal sand dune taxon-Sesuvium portulacastrum (L.). Bioscience Discovery. 2013; 4(1): 47-53.
- Panda S, Jafri M, Kar A, Meheta BK. Thyroid inhibitory, antiperoxidative and hypoglycemic effects of stigmasterol isolated from Butea monosperma. Fitoterapia. 2009, 80, 123–26.
- Tanaka K, Taniguchi S, Tamaoki D, Yoshitomi K, Akimitsu K, Gomi K. Multiple roles of plant volatiles in jasmonate induced defense response in rice. Plant Signal Behaviour. 2014; 9: 1-3.
- Srivastava R, Mukerjee A, Verma A. GC-MS analysis of phytocomponents in, pet ether fraction of Wrightia tinctoria seed. Phcognosy Journal. 2015; 7(4): 249-53.
- Paramanantham M, Murugesan A. GC-MS analysis of Holarrhena antidysentrica Wall flower. International Journal of Science Engineering and Technology Research. 2014; 3(3): 631-39.
- Yamuna P, Abirami P, Vijayashalini P, Sharmila M. GC-MS analysis of bioactive compounds in the entire plant parts of ethanolic extract of Gomphrena decumbens Jacq. Journal of Medicinal Plants Studies. 2017; 5(3): 31-37.
- Geetha DH, Rajeswari M, Jayashree I. Chemical profiling of Elaeocarpus serratus L. by GC-MS. Asian Pacific Journal of Tropical Biomedicine. 2013; 3(12): 985–87.
- Senguttuvan J, Paulsamy S, Karthika K. Phytochemical analysis and evaluation of leaf and ischolar_main parts of the medicinal herb, Hypochaeris radicata L. for in vitro antioxidant activities. Asian Pacific Journal of Tropical Biomedicine. 2014; 4(1): S359–67.
- Metal Analysis in Citrus sinensis Fruit Peel and Psidium guajava Leaf
Abstract Views :168 |
PDF Views:0
Authors
Affiliations
1 Department of Pharmaceutical Sciences, M. D. University, Rohtak, Haryana-124 001, IN
2 Division of Kidney Diseases & Hypertension, Feinstien Institute of Medical Research, Great Neck, New York – 11021, US
1 Department of Pharmaceutical Sciences, M. D. University, Rohtak, Haryana-124 001, IN
2 Division of Kidney Diseases & Hypertension, Feinstien Institute of Medical Research, Great Neck, New York – 11021, US
